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Color deficient users may have difficulties in perceiving certain color combinations. Don't assume that the color lightness you see will be the same as the lightness perceived by color deficient users.
It's recommended that you lighten your light colors and darken your dark colors to increase the visual accessibility of your Web site.
Test your Web pages with a monochrome monitor setting. If the elements of the page are clear, a color deficient user will probably be able to view your Web site effectively.
British Telecom's "Transforming Images (Safe Web Colours for colour-deficient vision)" Web site illustrates how users with different color deficiencies have a hard time distinguishing certain color combinations.
Conveying Meaning with Colors >>>